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Because BRCA1 carriers will be identified as having ER-negative breasts cancers, the authors remember that carriers of the mutations have to consider extra breast-cancer-risk-decrease strategies, such as for example intensive screening with breasts MRI or prophylactic mastectomy. Kauff.. Advantage of removal of the ovaries differs between ladies with BRCA2 and BRCA1 mutations The surgery of the ovaries has been widely adopted as a cancer-risk-reducing technique for women with either BRCA1 or BRCA2 mutations. A fresh multicenter research led by experts at Memorial Sloan-Kettering Malignancy Center may be the first prospective study of the impact of the procedure where BRCA2 mutation carriers had been analyzed individually from BRCA1 mutation carriers.