An accurate model of p53 tumor suppressor proteins bound to DNA for anti-cancer activity Over fifty % of individual cancers involve mutations in the p53 tumor-suppressor gene, suggesting the critical part played by the standard p53 proteins in defending against cancer. Similarly, approximately 95 % of cancer-leading to mutations in the p53 proteins happen in its DNA-binding core domain, pointing to the area of the p53 protein as being pivotal to its anti-cancer activity. Clearly, an in depth view of the p53 protein in direct connection with DNA could offer essential insights into preventing and treating a range of individual cancers here .