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‘ESCRTs are just like the recycling devices of the cell; they oversee the continuous intake, breakdown and replenishing of junctions on the cell surface area,’ described Dr Chalmers. ‘In a tumor cell where ESCRTs are broken, the junctions might not be restored properly; this may cause cells to migrate and separate to create secondary tumours in other areas of the body. ‘Previous studies show a connection between ESCRTs and the increased loss of junctions in cells of fruit flies, so you want to see whether this is especially true in humans.’ In this three year task, the researchers intend to block ESCRTs in cells grown in the laboratory to see the results on the junctions.